IMMUNOCORRECTION OF COWS FOR HYPOFUNCTION OF THE OVARIES

Abstract

The paper provides a theoretical justification and clinical verification of complex treatment schemes for cows with hypofunction of the ovaries with the involvement of immunocorrective drugs. The aim of the research was to study the dynamics of some blood indicators and the immune status of the body of cows with functional disorders of the ovaries under the influence of biostimulating drugs. The material for the research was cows of the Ukrainian dairy black and spotted breed with a diagnosis of hypofunction of the ovaries, which was manifested by anaphrodisia. The results of our research confirmed and supplemented the previously established data on changes in hematological and immunological indicators of the body of cows with hypofunction of the ovaries. It was established that the development of this pathology was accompanied by immunodeficiency, disorders of the cellular and humoral links of immunity, and a decrease in the indicators of non-specific protection of the body. Ovarian hypofunction of cows mainly develops against the background of immunosuppression, a decrease in the content of erythrocytes, hemoglobin and total protein in the blood, which indicates the need to use biostimulating therapy. The conducted analysis of the dynamics of the immune status indicators allows us to draw a conclusion about the versatile and specific immunotropic effect of the applied biological preparations. The obtained data show that the use of biogenic stimulants (hemostimulating serum, colostrum, ASD-f-2 drug) contributes to the normalization of the content of T- and B-lymphocytes, increases the functional activity of immunocompetent cells. The use of biostimulants had a positive effect on the dynamics of immunocompetent blood cells of sick animals of all experimental groups: at the end of the treatment, they practically equaled the control indicators. The greatest immunocorrective effect on the body of sick cows was shown by the simultaneous administration of colostrum with the drug ASD-f-2, which is evidenced by the high level of activation of immune and non-specific protection factors, the normalization of homeostasis indicators of their body and the restoration of the reproductive function of cows.