EFFECTIVENESS OF VARIOUS METHODS OF ADMINISTRATION OF ANTIBIOTICS IN COMPREHENSIVE SCHEMES OF TREATMENT OF COWS FOR POST-CALVATIONAL ENDOMETRITIS
DOI:
https://doi.org/10.37406/2706-9052-2025-1.37Keywords:
cow, uterus, endometritis, antibiotic, infection, exudate, therapy, inflammation, fertilityAbstract
Post-calvation diseases of the uterus are a serious problem of dairy cows, as they can affect a significant proportion of the population and have serious consequences for the reproductive ability of females and milk production. Therefore, the prevention and timely and effective treatment of puerperal complications should be considered as an important link in the system of measures to eliminate infertility and barrenness of cows. The paper presents the results of clinical and experimental studies on the regional use of antibiotics and stimulating drugs in comprehensive treatment schemes of cows for post-calvation endometritis. The basis of rational etiotropic and pathogenetic therapy was regional administration of drugs: into the internal iliac artery, paravaginally and intravaginally. Comprehensive and sequential treatment regimens for patients with endometritis in cows were scientifically substantiated, developed and tested. Clinical studies have shown that combined regional administration of enrofloxacin and metronidazole in combination with prostaglandin and a uterotonic drug turned out to be a more effective method of treating cows with purulent endometritis than their intramuscular injections. Injection of antimicrobial drugs into the main vessel that feeds the uterus allows to significantly concentrate their pharmacological action in the pathological focus. At the same time, the fertility of cows increased, the proportion of disease recurrence decreased, and the treatment period was shortened. Such a rational approach to improving therapy protocols allows reducing drug costs, which ensures its optimal pharmacoeconomic indicators. It was established that the combined administration of “broestrophan” and “docitol” due to the synergy of their action ensured active evacuation of exudate from the uterus and luteolysis, which positively affected the results of treatment and restoration of the reproductive function of cows.
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