EFFECT OF A COMPLEX FEED ADDITIVE WITH SORBENT AND HEPATOPROTECTIVE ACTION ON THE BIOCHEMICAL INDICATORS OF THE BLOOD OF REPLACEMENT PIGS

Abstract

Intensive industrial pig farming increases the requirements for breeding replacement gilts, as their metabolic and physiological condition determines their future productivity as the main breeding stock. The liver and kidneys play a key role in homeostasis, and their function is objectively reflected in blood biochemical parameters. The aim was to evaluate the effect of the complex feed additive “Gepasorbeх” at a dose of 1500 g/t of compound feed on the biochemical blood parameters of replacement gilts as integral markers of the functional state of the liver and the intensity of metabolic processes. The study was conducted on clinically healthy replacement sows of the Large White × Landrace combination, which were kept under industrial conditions at the Victoria private lease enterprise in the Bashtansky district of the Mykolaiv region. The animals were divided into a control group, which received a standard diet, and an experimental group, to which Gepasorbeх was added to the diet, with 40 animals in each group. At 190 days of age, blood serum biochemical parameters were determined in five animals from each group. It was found that the use of Gepasorbeх contributed to the improvement of the synthetic function of the liver, as confirmed by an increase in albumin content from 24.42 to 27.80 g/l (p < 0.05) and total protein from 54.24 to 58.49 g/l (p < 0.05). A pronounced positive effect on pigment metabolism was observed: the concentration of total bilirubin decreased from 7.49 to 2.64 μmol/l (p < 0.001), direct bilirubin decreased from 1.80 to 0.79 μmol/l (p < 0.05), and alkaline phosphatase activity normalized (173.34 → 115.85 U/L; p < 0.01). The use of the supplement was accompanied by stabilization of liver enzyme activity, manifested by a decrease in aspartate aminotransferase activity and optimization of the de Ritis index (1.26 → 0.84). In the experimental group, there was an improvement in energy and lipid metabolism, in particular an increase in glucose concentration within the physiological norm and a decrease in cholesterol content by 38.4 % (p < 0.01). Creatinine concentration increased to reference values (91.84 → 141.45 μmol/l; p<0.01), indicating intensification of metabolic processes without signs of renal dysfunction. Therefore, the inclusion of the complex feed supplement “Gepasorbeх” in the diets of replacement sows is advisable as an effective means of metabolic support and stabilization of the functional state of the liver in conditions of intensive pig farming.